Areas of expertise
Areas of expertise
The objective of a toxicological risk assessment (TRA) is to estimate or evaluate health risks posed to man and the environment by the use of chemicals. Hazard identification, exposure assessment and dose-response analysis are key characteristics to define the risk. KeyToxicology performs toxicological risk assessments to estimate the qualitative and quantitative health risks of a chemical and gives advice how to manage the risk. With respect to TRA, KeyToxicology provides the following services:
An endocrine disruptor is an exogenous substance or mixture, which causes adverse health effects in an intact organism by altering function(s) of the endocrine system. Recently the European Commision have published criteria to identify endocrine disruptors in plant protection products (Regulation (EC) No. 1107/2009) and in biocidal products (Regulation (EU) No. 528/2012). Based on these EU-ED criteria the European Food Safety Authority (EFSA) and European Chemical Agency (ECHA) published a joint guidance that describes the practical implementation of these regulations. KeyToxicology has been actively involved in this debate and can provide expert support with respect to endocrine disruptors taking the stepwise approach of the EFSA/ECHA guidance into account.
KeyToxicology has experience in and provides expert support for the establishment of:
Under EU regulation, new food products or ingredients who have not been consumed ‘significantly’ in the EU before May 1997 are called ‘novel foods’. Authorisation of the novel food is required before entering the EU market. KeyToxicology provides expert support with the preparation of the ADME characteristics and nutritional as well as toxicological information required to apply for authorisation of your novel food, as laid down in the EFSA guidance document.